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Anti-PSMA5 Antibody

CAT: 0519-M07499-80ulSize: 80 µLDry Ice: NoHazardous: No
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CAT#:0519-M07499-80ulSize:80 µL
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Background
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit.
Description
Boster Bio Anti-PSMA5 Antibody (Catalog # M07499) . Tested in WB, IF, IHC-P application (s) . This antibody reacts with Human, Mouse, Rat.
Synonyms
Proteasome subunit alpha type-5, Macropain zeta chain, Multicatalytic endopeptidase complex zeta chain, Proteasome zeta chain, PSMA5
Gene Name
PSMA5
UniProt
P28066
Host
Mouse
Reactivity
Human, Mouse, Rat
Immunogen
Purified His-tagged PSMA5 protein (Fragment) was used to produced this monoclonal antibody.
Clonality
Monoclonal
Clone
Clone: 426CT8.5.1
Tissue Specificity
Expressed in fetal brain (at protein level) .
Applications
WB, IF, IHC-P
Field of Research
Cell Biology, Proteasome
Purification
This antibody is purified through a protein G column, followed by dialysis against PBS.
Function
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin- independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex) .
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Observed Molecular Weight
26411 Da
Subcellular Location
Cytoplasm. Nucleus. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9
Prediction Reactivity
Bovine
Isotype
IgG1
Contents
Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

UniProtKB · P28066

Proteasome subunit alpha type-5

PSA5_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P28066
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PSMA5
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B2R8F6, B4E2V4, Q3T1C1, Q6IBF7
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationGlycoproteinPhosphoprotein

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmNucleusProteasome

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