Anti- (DANRE) srrt Antibody (C-Term)

• Background :

  Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs (By similarity) . Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self- renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity) .

• Description :

  Boster Bio Anti- (DANRE) srrt Antibody (C-Term) (Catalog # M05444) . Tested in WB application (s) . This antibody reacts with Human, Zebrafish.

• Synonyms :

  Serrate RNA effector molecule homolog, Arsenite-resistance protein 2, srrt, ars2

• Gene Name :

  Srrt

• UniProt :

  Q66I22

• Host :

  Rabbit

• Reactivity :

  Human, Zebrafish

• Immunogen :

  This DANRE srrt antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 733-766 amino acids from DANRE srrt.

• Clonality :

  Polyclonal

• Applications :

  WB

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Function :

  Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs (By similarity) . Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity) .

• Storage Conditions :

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Observed Molecular Weight :

  103274 Da

• Applications Notes :

  WB: 1:2000

• Subcellular Location :

  Nucleus, nucleoplasm. Cytoplasm. Note=Predominantly nuclear. Shuttles between the nucleus and the cytoplasm (By similarity) .

• Isotype :

  Rabbit IgG

• Contents :

  Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.