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Anti- (DANRE) srrt Antibody (C-Term)

CAT: 0519-M05444-200ulSize: 200 µLDry Ice: NoHazardous: No
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CAT#:0519-M05444-200ulSize:200 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs (By similarity) . Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self- renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity) .
Description
Boster Bio Anti- (DANRE) srrt Antibody (C-Term) (Catalog # M05444) . Tested in WB application (s) . This antibody reacts with Human, Zebrafish.
Synonyms
Serrate RNA effector molecule homolog, Arsenite-resistance protein 2, srrt, ars2
Gene Name
Srrt
UniProt
Q66I22
Host
Rabbit
Reactivity
Human, Zebrafish
Immunogen
This DANRE srrt antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 733-766 amino acids from DANRE srrt.
Clonality
Polyclonal
Applications
WB
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs (By similarity) . Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity) .
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Observed Molecular Weight
103274 Da
Applications Notes
WB: 1:2000
Subcellular Location
Nucleus, nucleoplasm. Cytoplasm. Note=Predominantly nuclear. Shuttles between the nucleus and the cytoplasm (By similarity) .
Isotype
Rabbit IgG
Contents
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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