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Anti-CD276 Antibody

CAT: 0519-M02220-3-50ulSize: 50 µLDry Ice: NoHazardous: No
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CAT#:0519-M02220-3-50ulSize:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.
Description
Boster Bio Anti-CD276 Antibody (Catalog # M02220-3) . Tested in WB, IHC-P application (s) . This antibody reacts with Human.
Synonyms
CD276 antigen, 4Ig-B7-H3, B7 homolog 3, B7-H3, Costimulatory molecule, CD276, CD276, B7H3
Gene Name
CD276
UniProt
Q5ZPR3
Host
Mouse
Reactivity
Human
Immunogen
This CD276 antibody is generated from a mouse immunized with a recombinant protein from the human region of human CD276.
Clonality
Monoclonal
Clone
Clone: 2009CT652.35.9
Tissue Specificity
Ubiquitous but not detectable in peripheral blood lymphocytes or granulocytes. Weakly expressed in resting monocytes Expressed in dendritic cells derived from monocytes. Expressed in epithelial cells of sinonasal tissue. Expressed in extravillous trophoblast cells and Hofbauer cells of the first trimester placenta and term placenta.
Applications
WB, IHC-P
Field of Research
Cancer, Immunology, Stem Cells
Purification
This antibody is purified through a protein G column, followed by dialysis against PBS.
Function
May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Observed Molecular Weight
57235 Da
Subcellular Location
Membrane; Single-pass type I membrane protein
Prediction Reactivity
Human
Isotype
IgG1, κ
Contents
Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

UniProtKB · Q5ZPR3

CD276 antigen

CD276_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q5ZPR3
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CD276
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
Q6P5Y4, Q6UXI2, Q8NBI8, Q8NC34, Q8NCB6, Q9BXR1
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

PTM

Disulfide bondGlycoproteinPhosphoprotein

Domain

Immunoglobulin domainRepeatSignalTransmembraneTransmembrane helix

Cellular component

Membrane

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