Products for Research Use Only
RegisterLogin

PHPS1

CAT: 0804-HY-112368-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-112368-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
PHPS1 is a potent and selective Shp2 inhibitor with Kis of 0.73, 5.8, 10.7, 5.8, and 0.47 μM for Shp2, Shp2-R362K, Shp1, PTP1B, and PTP1B-Q, respectively[1].
CAS Number
314291-83-3
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Phosphatase; SHP1; SHP2
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/phps1.html
Purity
99.77
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=S(C1=CC=C(N/N=C2C(C3=CC=C([N+]([O-])=O)C=C3)=NN(C4=CC=CC=C4)C\2=O)C=C1)(O)=O
Molecular Formula
C21H15N5O6S
Molecular Weight
465.44
Precautions
H315, H319, H335
References & Citations
[1]Klaus Hellmuth, et al. Specific Inhibitors of the Protein Tyrosine Phosphatase Shp2 Identified by High-Throughput Docking. Proc Natl Acad Sci U S A. 2008 May 20;105 (20) :7275-80.|[2]Jia Chen, et al. SHP2 Inhibitor PHPS1 Protects Against Atherosclerosis by Inhibiting Smooth Muscle Cell Proliferation. BMC Cardiovasc Disord. 2018 Apr 27;18 (1) :72.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-P75975-01PHPT1, Human (His)
HY-P71769PHPT1, Human (P.pastoris, His)
HY-RS10453PHPT1 Human Pre-designed siRNA Set A
HY-RS17838Phpt1 Mouse Pre-designed siRNA Set A
HY-RS24306Phpt1 Rat Pre-designed siRNA Set A

Alternative Products

CatalogName
T28410-01PHPS1
CXB13102-01Phps1 sodium
6771/5PHPS1 sodium salt
sc-222226PTP Inhibitor V, PHPS1
304196-01ABHD2 (ABHD2, LABH2, Abhydrolase domain-containing protein 2, Lung alpha/beta hydrolase 2, Protein PHPS1-2)
031492ABHD2, ID (ABHD2, LABH2, Abhydrolase domain-containing protein 2, Lung alpha/beta hydrolase 2, Protein PHPS1-2)
MBS6270554-01ABHD2, ID (ABHD2, LABH2, Abhydrolase domain-containing protein 2, Lung alpha/beta hydrolase 2, Protein PHPS1-2) (FITC)
MBS6270560-01ABHD2, ID (ABHD2, LABH2, Abhydrolase domain-containing protein 2, Lung alpha/beta hydrolase 2, Protein PHPS1-2) (MaxLight 750)

Popular Products