Anti-MOB4A Antibody (C-term)

CAT: 0519-A09405-3-400ulSize: 400 µLDry Ice: NoHazardous: No

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CAT#:0519-A09405-3-400ulSize:400 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

MOB4A is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Mob4A regulates NDR1 and NDR2 kinase activity, widely expressed nuclear serine-threonine kinases that have been implicated in cell proliferation and/or tumor progression.

Description

Boster Bio Anti-MOB4A Antibody (C-term) (Catalog # A09405-3) . Tested in WB, IHC-P, IF application (s) . This antibody reacts with Human, Mouse.

Synonyms

MOB kinase activator 1B, Mob1 homolog 1A, Mob1A, Mob1B, Mps one binder kinase activator-like 1A, MOB1B, MOB4A, MOBKL1A

Gene Name

MOB1B

UniProt

Q7L9L4

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This MOB4A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 177-206 amino acids from the C-terminal region of human MOB4A.

Clonality

Polyclonal

Tissue Specificity

Adrenal gland, bone marrow, brain, lung, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, uterus, colon with mucosa, fetal brain and fetal liver

Applications

WB, IHC-P, IF

Field of Research

Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Function

Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

25091 Da

Subcellular Location

Cytoplasm. Nucleus

Prediction Reactivity

Rat

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

UniProtKB · Q7L9L4

MOB kinase activator 1B

MOB1B_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q7L9L4
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: MOB1B
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: B2R8U6, B4DRY3, Q8IY23

Protein keywords

PTM

AcetylationPhosphoprotein

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmNucleus

Ligand

Metal-bindingZinc

Technical term

Proteomics identificationReference proteome

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