Anti-MAP1 MOAP1 Antibody

CAT: 0519-A08043Size: 0.1 mgDry Ice: NoHazardous: No
CAT#:0519-A08043Size:0.1 mg
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Background
Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Members of the Bcl-2 family are known to be critical regulators of this process. These proteins are characterized by the presence of several conserved motifs termed Bcl-2 homology (BH) domains. A related protein termed MAP-1 has recently been identified. This protein contains a BH3-like domain and induces caspase-dependent apoptosis in mammalian cells when overexpressed. It forms homodimers and associates with Bcl-2 family members such as Bax, Bcl-2, and Bcl-XL in vitro and in vivo. It has been suggested that MAP-1 associates with the tumor suppressor RASSF1A following death receptor activation, allowing a conformational change in Bax that leads to cellular apoptosis.
Description
Boster Bio Anti-MAP1 MOAP1 Antibody (Catalog # A08043) . Tested in ELISA, WB applications. This antibody reacts with Human, Mouse.
Synonyms
MAP-1, PNMA4, Modulator of apoptosis 1, Paraneoplastic antigen Ma4, MAP-1
Gene Name
MOAP1
UniProt
Q96BY2
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
MAP-1 antibody was raised against a 15 amino acid synthetic peptide from near the center of human MAP-1. The immunogen is located within the last 50 amino acids of MAP1.
Clonality
Polyclonal
Tissue Specificity
Widely expressed, with high levels in heart and brain.
Applications
ELISA, WB
Field of Research
Apoptosis, Neuroscience, Signal Transduction
Purification
MAP1 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL
Form
Liquid
Function
Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation.
Storage Conditions
MAP1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Observed Molecular Weight
39513 MW
Gene Name Synonym
Modulator of apoptosis 1
Subcellular Location
Cytoplasm
Protein Name
Modulator of apoptosis 1
Isotype
IgG
Contents
MAP1 Antibody is supplied in PBS containing 0.02% sodium azide.

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