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Anti-UPF2 Antibody

CAT: 0519-A03627Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0519-A03627Size:100 µL
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Description
Boster Bio Anti-UPF2 Antibody catalog # A03627. Tested in WB, IHC applications. This antibody reacts with Human, Rat.
Synonyms
Regulator of nonsense transcripts 2; Nonsense mRNA reducing factor 2; Up-frameshift suppressor 2 homolog; hUpf2; UPF2; KIAA1408, RENT2
Gene Name
UPF2
UniProt
Q9HAU5
Host
Rabbit
Reactivity
Human, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1153-1272 of human UPF2 (NP_542166.1) .
Clonality
Polyclonal
Tissue Specificity
Ubiquitous.
Applications
WB, IHC
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) . Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA.
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
147810 MW
Gene Name Synonym
Regulator of nonsense transcripts 2
Subcellular Location
Cytoplasm, perinuclear region
Protein Name
Regulator of nonsense transcripts 2
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

UniProtKB · Q9HAU5

Regulator of nonsense transcripts 2

RENT2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9HAU5
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
UPF2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A6NLJ5, D3DRS0, Q14BM1, Q5W0J4, Q8N8U1, Q9H1J2, Q9NWL1, Q9P2D9, Q9Y4M9
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Domain

Coiled coilRepeat

Cellular component

Cytoplasm

Biological process

Nonsense-mediated mRNA decay

PTM

Phosphoprotein

Molecular function

RNA-binding

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Alternative Products

CatalogName
STJ115373Anti-UPF2 antibody
STJ70845Anti-RENT2 / UPF2 antibody
OACA08214-50ULUPF2 Antibody
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