Anti-PRKACA Antibody

CAT: 0519-A00653-3Size: 100 µLDry Ice: NoHazardous: No

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CAT#:0519-A00653-3Size:100 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. Tissue-specific isoforms that differ at the N-terminus have been described, and these isoforms may differ in the post-translational modifications that occur at the N-terminus of some isoforms.

Description

Boster Bio Anti-PRKACA Antibody catalog # A00653-3. Tested in WB, IHC, IP, ELISA applications. This antibody reacts with Human.

Gene Name

PRKACA

UniProt

P17612

Host

Rabbit

Reactivity

Human

Immunogen

E.coli-derived human PRKACA recombinant protein (Position: 164-348) .

Clonality

Polyclonal

Applications

WB, IHC, IP, ELISA

Purification

Immunogen affinity purified.

Concentration

500 μg/mL

Form

Liquid

Storage Conditions

12 months from date of receipt, -20°C as supplied. 6 months 2 to 8°C after reconstitution. Avoid repeated freezing and thawing.

Contents

500 μg/mL antibody with PBS,0.02% NaN3, 1 mg BSA and 50% glycerol.

UniProtKB · P17612

cAMP-dependent protein kinase catalytic subunit alpha

KAPCA_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P17612
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: PRKACA
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: PKA C-alpha
EC number: 2.7.11.11
Processing: —
Secondary accessions: Q32P54, Q9H2Y0, Q9NRB4, Q9NRH9

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingcAMPNucleotide-binding

Cellular component

Cell membraneCell projectionCiliumCytoplasmCytoplasmic vesicleFlagellumMembraneMitochondrionNucleus

Disease

Cushing syndromeDisease variant

Molecular function

KinaseSerine/threonine-protein kinaseTransferase

PTM

LipoproteinMyristatePhosphoprotein

Related Products

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M00653-1-40μl	Anti-PRKACA Rabbit Monoclonal Antibody
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P00653-1	Anti-Phospho-PRKACA (S339) Antibody
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A00653T197	Anti-PKA Alpha / Beta cat (phospho-T197) PRKACA Antibody

Alternative Products

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STJ73243	Anti-PRKACA antibody
MBS423661-01	Goat anti-PRKACA Antibody
TMAB-11735-01	Anti-PRKACA Polyclonal Antibody
SL7479R-01	Rabbit Anti-PRKACA antibody
RHD25101	Anti-PRKACA Antibody (R1Q49)
HB890014-01	Anti-Human PRKACA Polyclonal Antibody
70R-4594	PRKACA antibody