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1-Dodecylimidazole

CAT: 0804-HY-138540-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-138540-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
1-Dodecylimidazole (N-Dodecylimidazole) is a lysosomotropic detergent and a cytotoxic agent. 1-Dodecylimidazole causes cell death by its acid-dependent accumulation in lysosomes, disruption of the lysosomal membrane, and releaseof cysteine proteases into the cytoplasm. 1-Dodecylimidazole has hypocholesterolaemic activity and broad-spectrum antifungal activity[1][2][3].
CAS Number
4303-67-7
Product Name Alternative
N-Dodecylimidazole
UNSPSC
12352200
Hazard Statement
H302, H315, H319, H335
Target
Fungal
Type
Biochemical Assay Reagents
Related Pathways
Anti-infection
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/1-dodecylimidazole.html
Purity
99.78
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CCCCCCCCCCCCN1C=CN=C1
Molecular Formula
C15H28N2
Molecular Weight
236.40
Precautions
H302, H315, H319, H335
References & Citations
[1]Wilson PD, et al. A relationship between multidrug resistance and growth-state dependent cytotoxicity of the lysosomotropic detergent N-dodecylimidazole. Biochem Biophys Res Commun. 1991;176 (3) :1377-1382.|[2]Atkin SD, et al. The isolation of 2,3-oxidosqualene from the liver of rats treated with 1-dodecylimidazole, a novel hypocholesterolaemic agent. Biochem J. 1972;130 (1) :153-157.|[3]Firestone RA, et al. Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents. J Med Chem. 1987;30 (8) :1519-1521.|[4]Boyer MJ, et al. pH dependent cytotoxicity of N-dodecylimidazole: a compound that acquires detergent properties under acidic conditions. Br J Cancer. 1993;67 (1) :81-87.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Biochemical Assay Reagents
Clinical Information
No Development Reported

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