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Anti-Complement C9 Antibody Picoband®

CAT: 0519-A01010-2Size: 100 µg/VialDry Ice: NoHazardous: No
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CAT#:0519-A01010-2Size:100 µg/Vial
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Complement component 9 is a protein involved in the complement system. It participates in the formation of the Membrane Attack Complex (MAC) . The MAC assembles on bacterial membranes to form a pore, permitting disruption of bacterial membrane organization. Mutations in this gene cause component C9 deficiency. And this gene is mapped to 5p13.1.
Description
Boster Bio Anti-Complement C9 Antibody Picoband® catalog # A01010-2. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Synonyms
Complement component C9; Complement component C9a; Complement component C9b; C9
Gene Name
C9
Gene ID
735
UniProt
P02748
Host
Rabbit
Reactivity
Human, Mouse
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E. coli-derived human Complement C9 recombinant protein (Position: K289-N515) .
Clonality
Polyclonal
Tissue Specificity
Plasma.
Applications
ELISA, WB
Field of Research
Complement, Immunology, Innate Immunity
Purification
Immunogen affinity purified.
Concentration
Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Form
Lyophilized
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Function
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC.
References & Citations
1. Coto, E., Martinez-Naves, E., Dominguez, O., DiScipio, R. G., Urra, J. M., Lopez-Larrea, C.DNA polymorphism and linkage relationship of the human complement component C6, C7, and C9 genes. Immunogenetics 33: 184-187, 1991. 2. Hobart, M. J., Fernie, B. A., Wurzner, R., Oldroyd, R. G., Harrison, R. A., Joysey, V., Lachmann, P. J. Difficulties in the ascertainment of C9 deficiency: lessons to be drawn from a compound heterozygote C9-deficient subject. Clin. Exp. Immun. 108: 500-506, 1997.
Storage Conditions
Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
63173 MW
Observed Molecular Weight
80 kDa
Specificity
No cross reactivity with other proteins.
Gene Name Synonym
Complement component C9
Subcellular Location
Secreted. Cell membrane; Multi-pass membrane protein. Secreted as soluble monomer. Oligomerizes at target membranes, forming a pre-pore. A conformation change then leads to the formation of a 100 Angstrom diameter pore.
Isotype
Rabbit IgG
Contents
243

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