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Anti-Complement C7 Antibody Picoband®

CAT: 0519-A00844-1Size: 100 µg/VialDry Ice: NoHazardous: No
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CAT#:0519-A00844-1Size:100 µg/Vial
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Background
This gene encodes a serum glycoprotein that forms a membrane attack complex together with complement components C5b, C6, C8, and C9 as part of the terminal complement pathway of the innate immune system. The protein encoded by this gene contains a cholesterol-dependent cytolysin/membrane attack complex/perforin-like (CDC/MACPF) domain and belongs to a large family of structurally related molecules that form pores involved in host immunity and bacterial pathogenesis. This protein initiates membrane attack complex formation by binding the C5b-C6 subcomplex and inserts into the phospholipid bilayer, serving as a membrane anchor. Mutations in this gene are associated with a rare disorder called C7 deficiency.
Description
Boster Bio Anti-Complement C7 Antibody Picoband® catalog # A00844-1. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Synonyms
Complement component C7; C7
Gene Name
C7
Gene ID
730
UniProt
P10643
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E. coli-derived human Complement C7 recombinant protein (Position: R233-D453) .
Clonality
Polyclonal
Tissue Specificity
Widely expressed.
Applications
WB, ELISA
Field of Research
Angiogenesis, Cancer, Cardiovascular, Developmental Biology, Embryogenesis, Growth Factors, Growth Factors/Hormones, Lineage Specification, Mesenchymal Stem Cells, Signal Transduction, Stem Cells
Purification
Immunogen affinity purified.
Concentration
Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Form
Lyophilized
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Function
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C7 serves as a membrane anchor.
References & Citations
1. Barroso, S., Rieubland, C., Alvarez, A. J., Lopez-Trascasa, M., Bart, P.-A., Nunez-Roldan, A., Sanchez, B. Molecular defects of the C7 gene in two patients with complement C7deficiency. Immunology 118: 257-260, 2006. 2. Coto, E., Martinez-Naves, E., Dominguez, O., DiScipio, R. G., Urra, J. M., Lopez-Larrea, C.DNA polymorphism and linkage relationship of the human complement component C6, C7, and C9 genes. Immunogenetics 33: 184-187, 1991.
Storage Conditions
Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
55914 MW
Observed Molecular Weight
93 kDa
Specificity
No cross reactivity with other proteins.
Gene Name Synonym
Complement C7
Subcellular Location
Secreted.
Protein Name
Protein argonaute-1
Isotype
Rabbit IgG
Contents
243

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