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MDM2 Polyclonal Antibody

CAT: 0749-ABP0134Size: 100 µLDry Ice: NoHazardous: No
CAT#:0749-ABP0134Size:100 µL
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Background
MDM2 encodes a nuclear-localized E3 ubiquitin ligase. The MDM2 proto-oncogene can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.
Description
Rabbit Anti-MDM2 Polyclonal Antibody
Product Name Alternative
MDM2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein; Hdm2; Oncoprotein Mdm2; p53-binding protein Mdm2
Gene ID
4193
Accession Number
Q00987
Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived from the C-terminal region of human MDM2
Clonality
Polyclonal
Tag
E3 ubiquitin-protein ligase Mdm2
Applications
IF, WB, IHC, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
55kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
MDM2 Polyclonal Antibody detects endogenous levels of MDM2 protein.
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IF 1:50-200; WB 1:500-1:2000; IHC: 1:100-300; ELISA 1:20000; Not yet tested in other applications
Other Product Names
MDM2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein; Hdm2; Oncoprotein Mdm2; p53-binding protein Mdm2
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/Q00987
Isotype
Rabbit IgG

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