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Polyclonal Antibody to MDM2

CAT: 0793-35-1686-100Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0793-35-1686-100Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MDM2, a ubiquitin ligase for p53, plays a central role in regulation of the stability of p53 . Akt-mediated phosphorylation of MDM2 at Ser166 and Ser186 increases its interaction with p300, allowing MDM2-mediated ubiquitination and degradation of p53 . Phosphorylation of MDM2 also blocks its binding to p19ARF, increasing the degradation of p53 .
Product Name Alternative
HDMX|| hdm2
Gene Name
MDM2
Gene ID
4193
UniProt
Q00987
Host
Rabbit
Reactivity
Human
Immunogen
Peptide sequence around aa.18~22 (Q-I-P-A-S) derived from Human MDM2.
Target Antigen
MDM2
Clonality
Polyclonal
Applications
WB
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 90kd, Western blotting: 1:500~1:1000
Isotype
Rabbit IgG

UniProtKB · Q00987

E3 ubiquitin-protein ligase Mdm2

MDM2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q00987
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MDM2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.3.2.27
Processing
—
Secondary accessions
A6NL51, A8K2S6, Q13226, Q13297, Q13298, Q13299, Q13300, Q13301, Q53XW0, Q71TW9, Q8WYJ1, Q8WYJ2, Q9UGI3, Q9UMT8
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisHost-virus interactionUbl conjugation pathway

Cellular component

CytoplasmNucleus

Ligand

Metal-bindingZinc

PTM

PhosphoproteinUbl conjugation

Disease

Proto-oncogene

Molecular function

Transferase

Domain

Zinc-finger

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