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Rabbit Polyclonal Antibody to PP4R2

CAT: 1725-P42597-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:1725-P42597-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4) . May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair.Hastie C.J., Biochem. J. 347:845-855 (2000) .Zhang W., Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases.Mural R.J., Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Product Name Alternative
MGC131930; PP4R2; protein phosphatase 4; regulatory subunit 2
Swiss Prot
Q9NY27
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived from internal of human PP4R2.
Clonality
Polyclonal
Applications
WB
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Formulation
Purified antibody in PBS with 0.05% sodium azide.
Antibody Type
Primary antibody
Protein Name
PP4R2
Bands Size
50kDa

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