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Rabbit Polyclonal Antibody to BAZ2A

CAT: 1725-P42323-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:1725-P42323-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing By similarity.Jones M.H., Genomics 63:40-45 (2000) .Bechtel S., BMC Genomics 8:399-399 (2007) .Scherer S.E., Nature 440:346-351 (2006) .
Product Name Alternative
BA2A; BAZ2A; bromodomain adjacent to zinc finger domain 2A; hWALp3; KIAA0314
Swiss Prot
Q9UIF9
Host
Rabbit
Reactivity
Human
Immunogen
Synthesized peptide derived from internal of human BAZ2A.
Clonality
Polyclonal
Applications
WB
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Formulation
Purified antibody in PBS with 0.05% sodium azide.
Antibody Type
Primary antibody
Protein Name
BAZ2A
Bands Size
210kDa

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