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Rabbit Polyclonal Antibody to COPS5

CAT: 1725-P42072-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:1725-P42072-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Promotes the proteasomal degradation of BRSK2.Claret F.-X., Nature 383:453-457 (1996) .Asano K., J. Biol. Chem. 272:27042-27052 (1997) .The MGC Project Team, Genome Res. 14:2121-2127 (2004) .
Product Name Alternative
EC 3.4.-.-; Signalosome subunit 5; SGN5; Jun activation domain-binding protein 1
Swiss Prot
Q92905
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived from internal of human COPS5.
Clonality
Polyclonal
Applications
WB
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Formulation
Purified antibody in PBS with 0.05% sodium azide.
Antibody Type
Primary antibody
Protein Name
COPS5
Bands Size
38kDa

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