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Rabbit Polyclonal Antibody to ROR2

CAT: 1725-P34446-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:1725-P34446-01Size:50 µL
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Description
ROR2 is a tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development. This Type I membrane protein is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. Defects in ROR2 are a cause of brachydactyly type B1 (BDB1) . BDB1 is an autosomal dominant skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In BDB1 the middle phalanges are short but in addition the terminal phalanges are rudimentary or absent. Both fingers and toes are affected. The thumbs and big toes are usually deformed. Defects in ROR2 are a cause of recessive Robinow syndrome (RRS) . RRS is an autosomal disorder characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly and a dysmorphic facial appearance. The protein contains 1 frizzled (FZ) domain, 1 immunoglobulin-like C2-type domain, and 1 kringle domain.
Product Name Alternative
Tyrosine-protein kinase transmembrane receptor ROR2, Neurotrophic tyrosine kinase, receptor-related 2, ROR2, NTRKR2
Swiss Prot
Q01974
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This ROR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 915-943 amino acids from the C-terminal region of human ROR2.
Clonality
Polyclonal
Applications
WB, IHC-P
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Formulation
Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) .
Antibody Type
Primary antibody
Protein Name
ROR2
Bands Size
104.8kDa

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