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Rabbit Polyclonal Antibody to MOUSE Brd7

CAT: 1725-P33223-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:1725-P33223-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac) . Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase (By similarity) . Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24- mediated activation of transcriptional activation by AR.
Product Name Alternative
Bromodomain-containing protein 7, 75 kDa bromodomain protein, Brd7, Bp75
Swiss Prot
O88665
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This MOUSE Brd7 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 387-418 amino acids from the Central region of human MOUSE Brd7.
Clonality
Polyclonal
Applications
WB
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Formulation
Purified antibody in PBS with 0.05% sodium azide.
Antibody Type
Primary antibody
Protein Name
MOUSE Brd7
Bands Size
74.0kDa

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