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Rabbit Polyclonal Antibody to PCGF1

CAT: 1725-P33086-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:1725-P33086-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin- dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element) . Promotes cell cycle progression and enhances cell proliferation as well. May have a positive role in tumor cell growth by down- regulating CDKN1A. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
Product Name Alternative
Polycomb group RING finger protein 1, Nervous system Polycomb-1, NSPc1, RING finger protein 68, PCGF1, NSPC1, RNF68
Swiss Prot
Q9BSM1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
This PCGF1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 132-167 amino acids from the Central region of human PCGF1.
Clonality
Polyclonal
Applications
WB
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Antibody Type
Primary antibody
Protein Name
PCGF1
Bands Size
30.3kDa

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