Rabbit Polyclonal Antibody to (Mouse) Smarcd3

Plays a role in ATP dependent nucleosome remodeling by SMARCA4 containing complexes. Stimulates nuclear receptor mediated transcription (By similarity) . Belongs to the neural progenitors- specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex) . During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF) . The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3, 60 kDa BRG-1/Brm-associated factor subunit C, BRG1-associated factor 60C, BAF60C, mBAF60c, Smarcd3, Baf60c

Q6P9Z1

Human, Mouse, Rat

This Mouse Smarcd3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 158-193 amino acids from the Central region of Mouse Smarcd3.

WB

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Primary antibody

(Mouse) Smarcd3