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Rabbit Polyclonal Antibody to Mouse Cdk8

CAT: 1725-P32955-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:1725-P32955-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation (By similarity) .
Product Name Alternative
Cyclin-dependent kinase 8, Cell division protein kinase 8, Mediator complex subunit CDK8, Mediator of RNA polymerase II transcription subunit CDK8, Cdk8
Swiss Prot
Q8R3L8
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This Mouse Cdk8 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 424-458 amino acids from the C-terminal region of Mouse Cdk8.
Clonality
Polyclonal
Applications
WB
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Antibody Type
Primary antibody
Protein Name
Mouse Cdk8
Bands Size
53.2kDa

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Alternative Products

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MBS9415294-01CDK8 Polyclonal Antibody

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