AZM198

CAT: 0804-HY-W996116-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-W996116-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

AZM198 is a selective, orally active, and irreversible MPO inhibitor with an IC50 of 15.0 nM. AZM198 has an IC50 of 19 μM for CYP3A4. AZM198 has favorable lipophilicity, membrane permeability, metabolic stability, safety, and pharmacokinetic properties. AZM198 exhibits activity in improving vascular function, atherosclerotic plaques, pulmonary hypertension, kidney disease, visceral inflammatory fat deposition, ectopic fat deposition, and hepatic fibrosis[1].

CAS Number

1933460-23-1

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Cytochrome P450; Glutathione Peroxidase

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Field of Research

Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease

Smiles

O=C1NC(N(CC2=CC=C(C=C2CN)Cl)C3=C1NC=C3)=S

Molecular Formula

C14H13ClN4OS

Molecular Weight

320.80

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Inghardt T, et al. Discovery of AZD4831, a Mechanism-Based Irreversible Inhibitor of Myeloperoxidase, As a Potential Treatment for Heart Failure with Preserved Ejection Fraction. J Med Chem. 2022 Sep 8;65 (17) :11485-11496.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CYP3

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