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AZM198

CAT: 0931-T210789-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T210789-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1933460-23-1
Target
Cytochromes P450, Glutathione Peroxidase
Related Pathways
Metabolism
Bioactivity
AZM198 is a selective, orally active, and irreversible inhibitor of MPO with an IC50 of 15.0 nM. It exhibits an IC50 of 19 μM against CYP3A4 and possesses favorable lipophilicity, membrane permeability, metabolic stability, safety, and pharmacokinetic properties. AZM198 shows efficacy in improving vascular function, atherosclerotic plaques, pulmonary hypertension, nephropathy, visceral inflammatory fat deposition, ectopic fat deposition, and liver fibrosis.
Smiles
O=C1NC(=S)N(C=2C=CNC12)CC3=CC=C(Cl)C=C3CN
Molecular Formula
C14H13ClN4OS
Molecular Weight
320.8
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
HY-W996116-01AZM198

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