TJU103

CAT: 0804-HY-W795993Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-W795993Size:1 Each

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Description

TJU103 is a CD4 inhibitor. TJU103 inhibits autoreactive CD4+ T cells by disrupting the function of the CD4 during activation. TJU103 decreases mononuclear cell infiltration in brain and spinal cord tissue of experimental allergic encephalomyelitis (EAE) mice model. TJU103 downregulates Th1 and Th2 cytokine levels in response to proteolipid protein epitope 139-151 (PLPe) and exhibits inhibitory effects both after the appearance of EAE symptoms and upon rechallenge with Ag. TJU103 can be used for autoimmune diseases like EAE and sclerosis (MS) research[1].

CAS Number

10245-44-0

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Transmembrane Glycoprotein

Related Pathways

Immunology/Inflammation

Field of Research

Inflammation/Immunology

Smiles

O=C(C1=CC=NC=C1)N/N=C/C2=CNC3=C2C=CC=C3

Molecular Formula

C15H12N4O

Molecular Weight

264.28

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Edling AE, et al. An organic CD4 inhibitor reduces the clinical and pathological symptoms of acute experimental allergic encephalomyelitis. J Autoimmun. 2002 Mar;18 (2) :169-79.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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