M-APTA

CAT: 0804-HY-W750643-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-W750643-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
M-APTA (5'-S- (3-aminophenyl) -5'-thioadenosine) is a selective chemoprotective agent targeting methylthioadenosine phosphorylase (MTAP) . m-APTA can be converted into adenine, which is a crucial step in protecting normal cells from the toxicity of nucleobase analogues (NBA) . m-APTA is promising for research of MTAP-deficient cancers[1].
CAS Number
[86072-47-1]
Product Name Alternative
5′-S- (3-Aminophenyl) -5′-thioadenosine
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Phosphorylase
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Purity
99.54
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NC1=CC=CC(SC[C@@H]2[C@@H](O)[C@@H](O)[C@H](N3C=NC(C3=NC=N4)=C4N)O2)=C1
Molecular Formula
C16H18N6O3S
Molecular Weight
374.42
Precautions
H302, H315, H319, H335
References & Citations
[1]Zhang S, et al. 5'-S- (3-aminophenyl) -5'-thioadenosine, a novel chemoprotective agent for reducing toxic side effects of fluorouracil in treatment of MTAP-deficient cancers. Mol Cancer Ther. 2025 Mar 10.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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