M-APTA

• Description:

  M-APTA (5'-S- (3-aminophenyl) -5'-thioadenosine) is a selective chemoprotective agent targeting methylthioadenosine phosphorylase (MTAP) . m-APTA can be converted into adenine, which is a crucial step in protecting normal cells from the toxicity of nucleobase analogues (NBA) . m-APTA is promising for research of MTAP-deficient cancers[1].

• Product Name Alternative:

  5′-S- (3-Aminophenyl) -5′-thioadenosine

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Phosphorylase

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Cancer

• Purity:

  99.54

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  NC1=CC=CC(SC[C@@H]2[C@@H](O)[C@@H](O)[C@H](N3C=NC(C3=NC=N4)=C4N)O2)=C1

• Molecular Formula:

  C16H18N6O3S

• Molecular Weight:

  374.42

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Zhang S, et al. 5'-S- (3-aminophenyl) -5'-thioadenosine, a novel chemoprotective agent for reducing toxic side effects of fluorouracil in treatment of MTAP-deficient cancers. Mol Cancer Ther. 2025 Mar 10.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [86072-47-1]