2-Hydroxy Imiquimod

• Description :

  2-Hydroxy Imiquimod (R-842), a hydroxylated metabolite of Imiquimod (HY-B0180), is an immunomodulating agent. 2-Hydroxy Imiquimod can induce IFN-α, TNF-α, IL-1, IL-6 and IL-8 in human blood cells. 2-Hydroxy Imiquimod exhibits antivirus and antitumor activities. 2-Hydroxy Imiquimod can be used for the researches of cancer, infection and immunology[1][2].

• Product Name Alternative :

  R-842

• UNSPSC :

  12352005

• Target :

  Drug Metabolite; IFNAR; Interleukin Related; TNF Receptor

• Related Pathways :

  Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Cancer; Infection; Inflammation/Immunology

• Smiles :

  OC(C)(CN1C=NC2=C1C3=C(C=CC=C3)N=C2N)C

• Molecular Formula :

  C14H16N4O

• Molecular Weight :

  256.30

• References & Citations :

  [1]Weeks CE, et al. Induction of interferon and other cytokines by imiquimod and its hydroxylated metabolite R-842 in human blood cells in vitro. J Interferon Res. 1994 Apr;14 (2) :81-5.|[2]Imbertson LM, et al. Cytokine induction in hairless mouse and rat skin after topical application of the immune response modifiers imiquimod and S-28463. J Invest Dermatol. 1998 May;110 (5) :734-9.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  IL-1; IL-6; IL-8

• CAS Number :

  [112668-45-8]