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Zotepine-d6

CAT: 0804-HY-W744038Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-W744038Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Zotepine-d6 is the deuterium labeled Zotepine. Zotepine, an antipsychotic agent, is a potent antagonist of 5-HT2A, 5-HT2C, Histamine H1, α1-adrenergic and Dopamine D2 receptors, with Kds of 2.6 nM, 3.2 nM, 3.3 nM, 7.3 nM and 8 nM, respectively. Zotepine exhibits antidepressive and anxiolytic effects in vivo[1][2].
CAS Number
2512222-52-3
UNSPSC
12352005
Target
5-HT Receptor; Adrenergic Receptor; Dopamine Receptor; Histamine Receptor; Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling; Others
Field of Research
Neurological Disease
Smiles
ClC1=CC2=C(SC3=C(C=C2OCCN(C([2H])([2H])[2H])C([2H])([2H])[2H])C=CC=C3)C=C1
Molecular Formula
C18H12D6ClNOS
Molecular Weight
337.90
References & Citations
[1]Richelson E, et, al. Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68 (1) :29-39.|[2]Yamamura S, et, al. Effects of zotepine on extracellular levels of monoamine, GABA and glutamate in rat prefrontal cortex. Br J Pharmacol. 2009 Jun;157 (4) :656-65.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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