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Zotepine

CAT: 0804-HY-103093-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-103093-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Zotepine, an antipsychotic agent, is a potent antagonist of 5-HT2A, 5-HT2C, Histamine H1, α1-adrenergic and Dopamine D2 receptors, with Kds of 2.6 nM, 3.2 nM, 3.3 nM, 7.3 nM and 8 nM, respectively. Zotepine exhibits antidepressive and anxiolytic effects in vivo[1][2].
CAS Number
26615-21-4
UNSPSC
12352005
Hazard Statement
H301, H410
Target
5-HT Receptor; Adrenergic Receptor; Dopamine Receptor; Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/zotepine.html
Purity
99.80
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
ClC1=CC=C(SC2=CC=CC=C2C=C3OCCN(C)C)C3=C1
Molecular Formula
C18H18ClNOS
Molecular Weight
331.86
Precautions
H301, H410
References & Citations
[1]Richelson E, et, al. Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68 (1) :29-39.|[2]Yamamura S, et, al. Effects of zotepine on extracellular levels of monoamine, GABA and glutamate in rat prefrontal cortex. Br J Pharmacol. 2009 Jun;157 (4) :656-65.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
5-HT2 Receptor; α adrenergic receptor

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