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Rabbit Polyclonal Antibody to MeCP2

CAT: 1725-P30292-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:1725-P30292-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD) . Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of some cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.
Product Name Alternative
Methyl-CpG-binding protein 2, MeCp-2 protein, MeCp2, MECP2
Swiss Prot
P51608
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
This MeCP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 400-428 amino acids from human MeCP2.
Clonality
Polyclonal
Applications
WB
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Formulation
Purified antibody in PBS with 0.05% sodium azide.
Antibody Type
Primary antibody
Protein Name
MeCP2
Bands Size
52.4kDa

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