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Cicletanine (hydrochloride)

CAT: 0804-HY-W700616Size: 1 EachDry Ice: NoHazardous: No
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Description
Cicletanine hydrochloride is an orally active Furopyridine-derivative antihypertensive agent. Cicletanine hydrochloride stimulates NO release. Cicletanine hydrochloride induces effective pulmonary vasodilation[1][2].
CAS Number
82747-56-6
UNSPSC
12352005
Hazard Statement
H315-H319
Target
Drug Derivative; NO Synthase
Related Pathways
Immunology/Inflammation; Others
Field of Research
Cardiovascular Disease
Smiles
ClC1=CC=C(C2OCC3=C(C(C)=NC=C32)O)C=C1.Cl
Molecular Formula
C14H13Cl2NO2
Molecular Weight
298.16
Precautions
P264-P280-P302+P352-P305+P351+P338-P362+P364
References & Citations
[1]Saadjian A, et al. Long-term effects of cicletanine on secondary pulmonary hypertension. J Cardiovasc Pharmacol. 1998 Mar;31 (3) :364-71.|[2]Kalinowski L, et al. Cicletanine stimulates nitric oxide release and scavenges superoxide in endothelial cells. J Cardiovasc Pharmacol. 2001 Jun;37 (6) :713-24.
Shipping Conditions
Room temperature
Scientific Category
Reference compound2
Clinical Information
No Development Reported

Chemical Information

Cicletanine Hydrochloride

Cicletanine Hydrochloride is the hydrochloride salt of a dihydropyridine derivative with diuretic and antihypertensive activity. Cicletanine exerts thiazide-like diuretic activity. In addition, this agent inhibits protein kinase C (PKC) and is able to reverse vasoconstriction through the inhibition of PKC-mediated inhibition of Na/K-ATPase phosphorylation.

CAS Number82747-56-6
PubChem CID54909
IUPAC Name3-(4-chlorophenyl)-6-methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol;hydrochloride
Molecular FormulaC14H13Cl2NO2
Molecular Weight298.2
Topological Polar Surface Area42.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Heavy Atom Count19
Formal Charge0
Complexity294
SMILES
CC1=NC=C2C(OCC2=C1O)C3=CC=C(C=C3)Cl.Cl
InChI
InChI=1S/C14H12ClNO2.ClH/c1-8-13(17)12-7-18-14(11(12)6-16-8)9-2-4-10(15)5-3-9;/h2-6,14,17H,7H2,1H3;1H
InChIKey
QLMBAIRFQQLJJX-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Cicletanine Hydrochloride
CAS: 82747-56-6
CID: 54909
Formula: C14H13Cl2NO2
MW: 298.2
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight298.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Exact Mass297.0323340
Monoisotopic Mass297.0323340
Topological Polar Surface Area42.4 Ų
Heavy Atom Count19
Formal Charge0
Complexity294
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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