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ABS-752

CAT: 0804-HY-W599279Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-W599279Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ABS-752 is a potent and orally active GSPT1 and NEK7 molecular glue degrader. ABS-752 shows cytotoxicity. ABS-752 decreases the protein expression of GSPT1 and SALL4, NEK7. ABS-752 is a prodrug activated by the monoamine oxidase, VAP-1, to an aldehyde intermediate and subsequently to the active molecule, ABT-002. ABS-752 has the potential for the research of hepatocellular carcinoma[1].
CAS Number
2761170-84-5
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Molecular Glues; NEKs
Related Pathways
Cell Cycle/DNA Damage; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(C(N(CC1=C2C=C(F)C(CN)=C1)C2=O)CC3)NC3=O
Molecular Formula
C14H14FN3O3
Molecular Weight
291.28
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Przemysław Glaza, et al. Targeted degradation of GSPT1 and NEK7 by a molecular glue prodrug for treatment of HCC. Biorxiv. 2025.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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