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Benzylhydrochlorothiazide

CAT: 0804-HY-W587755Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-W587755Size:1 Each
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Description
Benzylhydrochlorothiazide is an orally active thiazide diuretic. Benzylhydrochlorothiazide acts on the distal convoluted tubules of the kidneys, inhibiting the reabsorption of sodium chloride, thereby increasing urine output and reducing the body's fluid volume. Benzylhydrochlorothiazide has phototoxicity and a potential risk of skin reactions. Benzylhydrochlorothiazide can cause cell death when exposed to UVA radiation. Benzylhydrochlorothiazide is used in research on hypertension and edema[1].
CAS Number
1824-50-6
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Sodium Channel
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Cardiovascular Disease
Smiles
O=S(C1=C(Cl)C=C(C2=C1)NC(CC3=CC=CC=C3)NS2(=O)=O)(N)=O
Molecular Formula
C14H14ClN3O4S2
Molecular Weight
387.86
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Inamoto N, et al. Porokeratosis of Mibelli: benzylhydrochlorothiazide-induced new lesions accompanied by eosinophilic spongiosis. J Am Acad Dermatol. 1984 Aug;11 (2 Pt 2) :357-61. |[2]Selvaag E, et al. Inhibiting effects of antioxidants on drug-induced phototoxicity in cell cultures. Investigations with sulphonamide-derived oral antidiabetics and diuretics. J Photochem Photobiol B. 1997 Mar;38 (1) :88-93.
Shipping Conditions
Room temperature
Scientific Category
Reference compound2
Clinical Information
No Development Reported

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