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Pyrraline

CAT: 0804-HY-W478741Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W478741Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pyrraline is an Nrf2 pathway activator with antioxidant and anti-inflammatory effects. Pyrraline upregulates antioxidant enzymes such as NAD (P) H dehydrogenase (NQO1) and heme oxygenase-1 (HO-1) via antioxidant response element (ARE) activation, while inhibiting NFκB-mediated inflammation. Pyrraline is promising for research of metabolic disorders (such as diabetic nephropathy) and cancers[1][2].
CAS Number
74509-14-1
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Endogenous Metabolite; Keap1-Nrf2; NF-κB
Related Pathways
Metabolic Enzyme/Protease; NF-κB
Field of Research
Cancer; Metabolic Disease
Smiles
C1=C(N(C(=C1)C=O)CCCC[C@@H](C(=O)O)N)CO
Molecular Formula
C12H18N2O4
Molecular Weight
254.28
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Hu C, et al. Untargeted metabolite profiling of serum in rats exposed to pyrraline. Food Sci Biotechnol. 2023 Jan 26;32 (11) :1541-1549.|[2]Raupbach J, et al. The Effect of Free and Protein-Bound Maillard Reaction Products N-ε-Carboxymethyllysine, N-ε-Fructosyllysine, and Pyrraline on Nrf2 and NFκB in HCT 116 Cells. Mol Nutr Food Res. 2023 Sep;67 (18) :e2300137.
Shipping Conditions
Room temperature
Scientific Category
Reference compound2
Clinical Information
No Development Reported

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