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ALizarin complexone (dihydrate)

CAT: 0804-HY-W320523Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-W320523Size:1 Each
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Description
ALizarin complexone dihydrate is the dehydrate of Alizarin complexone. Alizarin complexone is a calcium-binding fluorescent dye. Alizarin complexone stains mineralized areas of bone by binding to calcium crystals. Alizarin complexone inhibits the reverse transcriptase activity of RAV-2, HIV-1, and RSV with IC50 values of 3.8 μg/mL, 45 μg/mL, and 100 μg/mL, respectively. Alizarin complexone exhibits antiviral activity against HIV-1 and RSV. Alizarin complexone delays RSV-induced tumor induction in chickens[1][2][3][4].
CAS Number
455303-00-1
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Fluorescent Dye; HIV; Reverse Transcriptase; RSV
Related Pathways
Anti-infection; Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Infection; Metabolic Disease
Smiles
O=C(CN(CC(C=C1C2=O)=C(C(O)=C1C(C3=C2C=CC=C3)=O)O)CC(O)=O)O.O.O
Molecular Formula
C19H19NO10
Molecular Weight
421.35
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Higuchi H, et al. Antiretroviral activities of anthraquinones and their inhibitory effects on reverse transcriptase. Antiviral Res. 1991;15 (3) :205-216. |[2]Oshima T, et al. Selective extraction of histidine derivatives by metal affinity with a copper (II) -chelating ligand complex in an aqueous two-phase system. J Chromatogr B Analyt Technol Biomed Life Sci. 2015;990:73-79. |[3]Yu T, et al. Live imaging of osteoclast inhibition by bisphosphonates in a medaka osteoporosis model. Dis Model Mech. 2016 Feb;9 (2) :155-63. |[4]Cui M, et al. New role of calcium-binding fluorescent dye alizarin complexone in detecting permeability from articular cartilage to subchondral bone. FASEB Bioadv. 2024 Oct 7;6 (11) :539-554.
Shipping Conditions
Room temperature
Scientific Category
Biochemical Assay Reagents
Clinical Information
No Development Reported

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