Alizarin complexone

• Description:

  Alizarin complexone is a calcium-binding fluorescent dye. Alizarin complexone stains mineralized areas of bone by binding to calcium crystals. Alizarin complexone inhibits the reverse transcriptase activity of RAV-2, HIV-1, and RSV with IC50 values of 3.8 μg/mL, 45 μg/mL, and 100 μg/mL, respectively. Alizarin complexone exhibits antiviral activity against HIV-1 and RSV. Alizarin complexone delays RSV-induced tumor induction in chickens[1][2][3][4].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Fluorescent Dye; HIV; Reverse Transcriptase; RSV

• Type:

  Reference compound

• Related Pathways:

  Anti-infection; Others

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Cancer; Infection; Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/alizarin-complexone.html

• Purity:

  98.0

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  O=C(C1=C(C(O)=C(C=C1C2=O)CN(CC(O)=O)CC(O)=O)O)C3=C2C=CC=C3

• Molecular Formula:

  C19H15NO8

• Molecular Weight:

  385.32

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Higuchi H, et al. Antiretroviral activities of anthraquinones and their inhibitory effects on reverse transcriptase. Antiviral Res. 1991;15 (3) :205-216. |[2]Oshima T, et al. Selective extraction of histidine derivatives by metal affinity with a copper (II) -chelating ligand complex in an aqueous two-phase system. J Chromatogr B Analyt Technol Biomed Life Sci. 2015;990:73-79.|[3]Yu T, et al. Live imaging of osteoclast inhibition by bisphosphonates in a medaka osteoporosis model. Dis Model Mech. 2016 Feb;9 (2) :155-63. |[4]Cui M, et al. New role of calcium-binding fluorescent dye alizarin complexone in detecting permeability from articular cartilage to subchondral bone. FASEB Bioadv. 2024 Oct 7;6 (11) :539-554.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light, stored under nitrogen)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  HIV-1

• CAS Number:

  3952-78-1