Alizarin complexone

CAT: 0804-HY-121075-01Size: 1 gDry Ice: NoHazardous: No
CAT#:0804-HY-121075-01Size:1 g
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Description
Alizarin complexone is a calcium-binding fluorescent dye. Alizarin complexone stains mineralized areas of bone by binding to calcium crystals. Alizarin complexone inhibits the reverse transcriptase activity of RAV-2, HIV-1, and RSV with IC50 values of 3.8 μg/mL, 45 μg/mL, and 100 μg/mL, respectively. Alizarin complexone exhibits antiviral activity against HIV-1 and RSV. Alizarin complexone delays RSV-induced tumor induction in chickens[1][2][3][4].
CAS Number
[3952-78-1]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Fluorescent Dye; HIV; Reverse Transcriptase; RSV
Type
Reference compound
Related Pathways
Anti-infection; Others
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection; Endocrinology
Assay Protocol
https://www.medchemexpress.com/alizarin-complexone.html
Purity
98.0
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(C1=C(C(O)=C(C=C1C2=O)CN(CC(O)=O)CC(O)=O)O)C3=C2C=CC=C3
Molecular Formula
C19H15NO8
Molecular Weight
385.32
Precautions
H302, H315, H319, H335
References & Citations
[1]Higuchi H, et al. Antiretroviral activities of anthraquinones and their inhibitory effects on reverse transcriptase. Antiviral Res. 1991;15 (3) :205-216. |[2]Oshima T, et al. Selective extraction of histidine derivatives by metal affinity with a copper (II) -chelating ligand complex in an aqueous two-phase system. J Chromatogr B Analyt Technol Biomed Life Sci. 2015;990:73-79.|[3]Yu T, et al. Live imaging of osteoclast inhibition by bisphosphonates in a medaka osteoporosis model. Dis Model Mech. 2016 Feb;9 (2) :155-63. |[4]Cui M, et al. New role of calcium-binding fluorescent dye alizarin complexone in detecting permeability from articular cartilage to subchondral bone. FASEB Bioadv. 2024 Oct 7;6 (11) :539-554.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HIV-1

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