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(±) -Desisopropylpropranolol

CAT: 0804-HY-W192276Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-W192276Size:1 Each
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Description
(±) -Desisopropylpropranolol (N-Desisopropylpropranolol) is a metabolite of Propranolol. Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Kis of 1.8 nM and 0.8 nM, respectively. Propranolol inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM. Propranolol is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy[1][2][3][4].
CAS Number
20862-11-7
Product Name Alternative
N-Desisopropylpropranolol
UNSPSC
12352005
Hazard Statement
H315-H319-H320
Target
Adrenergic Receptor; Drug Metabolite
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling
Field of Research
Cancer; Endocrinology; Neurological Disease; Cardiovascular Disease
Smiles
C1=CC=C2C(=C1)C=CC=C2OCC(CN)O
Molecular Formula
C13H15NO2
Molecular Weight
217.26
Precautions
P264-P280-P302+P352-P305+P351+P338-P362
References & Citations
[1]Galandrin S, et al. Distinct signaling profiles of beta1 and beta2 adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacy. Mol Pharmacol. 2006 Nov;70 (5) :1575-84. |[2]Briley M, et al. Evidence against beta-adrenoceptor blocking activity of diltiazem, a drug with calcium antagonist properties. Br J Pharmacol. 1980 Aug;69 (4) :669-73. |[3]Al-Majed AA, et al. Propranolol. Profiles Drug Subst Excip Relat Methodol. 2017;42:287-338. |[4]ZHAO L, et al. LC/MS/MS determination of propranolol and its metabolites 4-hydroxypropranolol and N-desisopropylpropranolol in rat plasma[J]. Chinese Journal of Pharmaceutical Analysis, 2005, 25 (10) : 1203-1206.
Shipping Conditions
Room temperature
Scientific Category
Reference compound2
Clinical Information
No Development Reported
Isoform
β adrenergic receptor

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