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RAS-IN-5

CAT: 0804-HY-W1126467Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-W1126467Size:1 Each
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Description
RAS-IN-5 (Example 2) is a RAS inhibitor. RAS-IN-5 significantly inhibits the interaction between RAF1 and active KRAS mutant protein or HRAS WT protein. RAS-IN-5 significantly inhibits the cell viability of KRAS, NRAS, and EGFR mutant cells. RAS-IN-5 can be used in the research of colorectal cancer, liver cancer, and non-small cell lung cancer[1].
CAS Number
3061844-70-7
UNSPSC
12352005
Target
Ras
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
CCN1C2=C3C=C(C4=CC(C[C@@H](C(N5CCC[C@@H](C(OCC(C)(CC3=C1C6=C(C=CC(P(C)(C)=O)=C6)[C@@H](OC)C)C)=O)N5)=O)NC([C@@H](N(C([C@@H]7OCC[C@@H]7C8=CC=CC=C8)=O)C)C(C)C)=O)=CC(O)=C4)C=C2
Molecular Formula
C57H72N5O9P
Molecular Weight
1002.18
References & Citations
[1]TONG, et al. Macrocyclic compounds and therapeutic uses thereof. WO2024222864A1. WIPO (PCT) . 2024-04-26.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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