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Chloroxoquinoline

CAT: 0804-HY-W110138Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-W110138Size:1 Each
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Description
Chloroxoquinoline is an anticancer agent. Chloroxoquinoline damages the DNA templates of cancer cells, inducing DNA breaks and cell death, and inhibits cell invasion via down-regulating Rho/Rho kinase signaling pathway. Chloroxoquinoline enhances the radiation sensitivity of Lewis lung cancer cells and xenograft tumors in tumor-bearing mouse models but decreases efficacy after long term exposure in rat models by auto-induction effects on CYP1A and CYP3A. Chloroxoquinoline has a broad-spectrum anticancer activity, such as non-small-cell lung carcinoma (NSCLC), breast cancer and gastric cancer[1].
CAS Number
23833-97-8
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Cytochrome P450; DNA/RNA Synthesis; ROCK
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Metabolic Enzyme/Protease; Stem Cell/Wnt; TGF-beta/Smad
Field of Research
Cancer
Smiles
O=C1C=CNC2=C1C=CC(Cl)=C2
Molecular Formula
C9H6ClNO
Molecular Weight
179.60
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Li X, et al. Auto-Induction Effect of Chloroxoquinoline on the Cytochrome P450 Enzymes of Rats Associated with CYP 3A and 1A. PLoS One. 2015 Sep 23;10 (9) :e0138875. |[2]Liu J, et al. [Chloroxoquinoline inhibits invasion in breast cancer via down-regulating Rho/Rho kinase signaling pathway]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2019 Dec 25;48 (6) :631-637. Chinese.
Shipping Conditions
Room temperature
Scientific Category
Reference compound2
Clinical Information
No Development Reported

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