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Chloroxoquinoline

CAT: 0013-GTR19272974-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19272974-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Chloroxoquinoline is an anticancer agent that disrupts the DNA template of cancer cells, leading to DNA breaks and cell death. It inhibits cell invasion by downregulating the Rho/Rho kinase signaling pathway. In tumor-bearing mouse models, Chloroxoquinoline enhances the radiosensitivity of Lewis lung carcinoma cells and xenograft tumors. However, its long-term efficacy is reduced in rat models due to self-induction of CYP1A and CYP3A. Chloroxoquinoline exhibits broad-spectrum anticancer activity against non-small cell lung cancer (NSCLC), breast cancer, and gastric cancer.
CAS Number
23833-97-8
Smiles
O=C1C=CNC2=CC (Cl) =CC=C12
Molecular Formula
C9H6ClNO
Molecular Weight
179.6
Storage Conditions
-20°C
Notes
For research use only.

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