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Perfluorotetradecanoic acid

CAT: 0804-HY-W073128Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W073128Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Perfluorotetradecanoic acid (PFTeDA) is a PPARγ inhibitor. Perfluorotetradecanoic acid binds to human PPARγ ligand binding domain with IC50 of 22.8 μM, Kd of 157.8 μM. Perfluorotetradecanoic acid inhibits the function of Leydig cells by inducing oxidative stress and apoptosis. Perfluorotetradecanoic acid stimulates corticosterone biosynthesis but inhibits aldosterone production[1][2][3].
CAS Number
376-06-7
Product Name Alternative
PFTeDA
UNSPSC
12352211
Hazard Statement
H302+H332, H351, H360, H362, H372
Target
Apoptosis; PPAR
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Field of Research
Endocrinology
Purity
98.0
Smiles
O=C(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(F)F)F)F)F)F)F)F)F)F)F)F)F)F)O
Molecular Formula
C14HF27O2
Molecular Weight
714.11
Precautions
H302+H332, H351, H360, H362, H372
References & Citations
[1]Zhang L, et al. Structure-dependent binding and activation of perfluorinated compounds on human peroxisome proliferator-activated receptor γ. Toxicol Appl Pharmacol. 2014 Sep 15;279 (3) :275-283.|[2]Tang Y, et al. Leydig cell function in adult male rats is disrupted by perfluorotetradecanoic acid through increasing oxidative stress and apoptosis. Environ Toxicol. 2022 Jul;37 (7) :1790-1802.|[3]Ying Y, et al. Perfluorotetradecanoic acid exposure to adult male rats stimulates corticosterone biosynthesis but inhibits aldosterone production. Environ Toxicol. 2024 May;39 (5) :2610-2622.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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