L-Histidinol-d3

L-Histidinol-d3 ((S) -2-Amino-3- (1H-imidazol-5-yl) propan-1-ol-d3) is the deuterium labeled L-Histidinol. L-Histidinol is an orally active histidyl-tRNA synthetase inhibitor. L-Histidinol interferes with the initiation stage of protein synthesis, thus affecting cell proliferation and metabolism. L-Histidinol has the effect of modulating the sensitivity of tumor cells to chemotherapeutic agents. L-Histidinol reduces the toxicity of certain chemotherapeutic agents to normal tissues and enhance the sensitivity of tumor cells to chemotherapeutic agents[1][2][3][4][5][6][7][8][9][10].

12352005

Aminoacyl-tRNA Synthetase; Endogenous Metabolite; Isotope-Labeled Compounds

Metabolic Enzyme/Protease; Others

Cancer

OC([2H])([2H])[C@H](CC1=CN=C([2H])N1)N

C6H8D3N3O

144.19

[1]Kohnoe S, et al. L-histidinol potentiates hyperthermic cell-killing in-vitro. Int J Oncol. 1993 Nov;3 (5) :835-9. |[2]Warrington RC, et al. L-Histidinol inhibits specifically and reversibly protein and ribosomal RNA synthesis in mouse L cells. J Biol Chem. 1977 Aug 10;252 (15) :5251-7. |[3]Warrington RC, et al. Effects of L-histidinol on the susceptibility of P815 mastocytoma cells to selected anticancer drugs in vitro and in DBA/2J mice. J Natl Cancer Inst. 1987 Jun;78 (6) :1177-83. |[4]Warrington RC, et al. Reversal of the multidrug-resistant phenotype of Chinese hamster ovary cells by L-histidinol. J Natl Cancer Inst. 1989 May 10;81 (10) :798-803. |[5]Warrington RC, et al. L-histidinol protection against cytotoxic action of cytosine arabinoside and 5-fluorouracil in cultured mouse spleen cells. J Natl Cancer Inst. 1982 Feb;68 (2) :279-86.|[6]Zaharko D, et al. L-histidinol: preclinical therapeutic studies in combination with antitumor agents and pharmacokinetic studies in mice. Cancer Res. 1992 Jul 1;52 (13) :3604-9. |[7]Stolfi RL, et al. Chemotherapeutic activity of L-histidinol against spontaneous, autochthonous murine breast tumors. Chemotherapy. 1990;36 (6) :435-40.|[8]Badary OA. L-Histidinol attenuates Fanconi syndrome induced by ifosfamide in rats. Exp Nephrol. 1999 Jul-Aug;7 (4) :323-7.|[9]Warrington RC, et al. L-histidinol improves the selectivity and efficacy of alkylating agents and daunomycin in mice with P388 leukaemia. Br J Cancer. 1989 Nov;60 (5) :652-6.

Room temperature

Isotope-Labeled Compounds