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Tetraxetan

CAT: 0804-HY-W053583-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W053583-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tetraxetan (DOTA) is a macrocyclic chelating agent. Tetraxetan can form stable coordination complexes with a variety of metal ions (e.g., 68Ga, 111In, 177Lu) . Tetraxetan can be conjugated with targeting molecules (e.g., RGD peptide, folic acid) to enable the complex to target specific biomolecules or cells. Tetraxetan can be used for imaging studies of tumors, including melanoma and folate receptor-positive tumors (e.g., cervical cancer) [1][2][3].
CAS Number
60239-18-1
Product Name Alternative
DOTA
UNSPSC
12352200
Hazard Statement
H302, H315, H319, H335
Target
Biochemical Assay Reagents; Radionuclide-Drug Conjugates (RDCs)
Related Pathways
Antibody-drug Conjugate/ADC Related; Others
Field of Research
Cancer
Purity
99.95
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
O=C(O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1
Molecular Formula
C16H28N4O8
Molecular Weight
404.42
Precautions
H302, H315, H319, H335
References & Citations
[1]Orcutt KD, et al. Biodistribution and clearance of small molecule hapten chelates for pretargeted radioimmunotherapy. Mol Imaging Biol. 2011 Apr;13 (2) :215-21. |[2]Decristoforo C, et al. 68Ga- and 111In-labelled DOTA-RGD peptides for imaging of alphavbeta3 integrin expression. Eur J Nucl Med Mol Imaging. 2008 Aug;35 (8) :1507-15. |[3]Müller C, et al. DOTA conjugate with an albumin-binding entity enables the first folic acid-targeted 177Lu-radionuclide tumor therapy in mice. J Nucl Med. 2013 Jan;54 (1) :124-31.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Biochemical Assay Reagents
Clinical Information
Phase 2

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