Ac4GlcNAz

• Description:

  Ac4GlcNAz (N-azidoacetylglucosamine-tetraacylated) is an azido-tagged analogue of N-acetylglucosamine (GlcNAC) . It features azide functionality on the N-acyl side chain and is acetylated to aid in cell membrane permeation. Once in the cell, the acetylated compound is deprotected and takes part in the hexosamine biosynthetic pathway by action of GlcNAc kinase. The resulting modified proteins are detected by the addition of fluorescent tags under Cu (I) -catalyzed azide-alkyne cycloaddition conditions.

• Product Name Alternative:

  N-azidoacetylglucosamine-tetraacylated

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Biochemical Assay Reagents

• Related Pathways:

  Others

• Field of Research:

  Others

• Purity:

  99.60

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  CC(O[C@@H]1[C@H](C(O[C@@H]([C@H]1OC(C)=O)COC(C)=O)OC(C)=O)NC(CN=[N+]=[N-])=O)=O

• Molecular Formula:

  C16H22N4O10

• Molecular Weight:

  430.37

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Luong P, Ghosh A, Moulton KD, Kulkarni SS, Dube DH. Synthesis and Application of Rare Deoxy Amino l-Sugar Analogues to Probe Glycans in Pathogenic Bacteria. ACS Infect Dis. 2022 Apr 8;8 (4) :889-900. |[2]Clark EL, Emmadi M, Krupp KL, Podilapu AR, Helble JD, Kulkarni SS, Dube DH. Development of Rare Bacterial Monosaccharide Analogs for Metabolic Glycan Labeling in Pathogenic Bacteria. ACS Chem Biol. 2016 Dec 16;11 (12) :3365-3373.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound2

• Clinical Information:

  No Development Reported

• CAS Number:

  [98924-81-3]