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Ac4GalNAz

CAT: 0804-HY-141128-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-141128-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ac4GalNAz is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Ac4GalNAz is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
CAS Number
653600-56-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
PROTAC Linkers
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ac4galnaz.html
Purity
99.99
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(N[C@H]1C(OC(C)=O)O[C@H](COC(C)=O)[C@H](OC(C)=O)[C@@H]1OC(C)=O)CN=[N+]=[N-]
Molecular Formula
C16H22N4O10
Molecular Weight
430.37
Precautions
H302, H315, H319, H335
References & Citations
[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Alkyl-Chain Linkers

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CatalogName
T17348-01Ac4GalNAz
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JBS-CLK-1086-100Ac4GalNAz (100 mg)
JBS-CLK-1086-5Ac4GalNAz (5 mg)
3706-25mgAc4GalNAz (N-Azidoacetylgalactosamine-tetraacylated), 25 mg
3706-5mgAc4GalNAz (N-Azidoacetylgalactosamine-tetraacylated), 5 mg
3706-100mgAc4GalNAz (N-Azidoacetylgalactosamine-tetraacylated), 100 mg

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