Benzophenone-2

• Description:

  Benzophenone-2 (2,2',4,4'-Tetrahydroxybenzophenone) is an endocrine disruptor targeting pregnane X receptor (PXR) and estrogen receptor α (ERα) . Benzophenone-2 regulates cytochrome P450 3A (CYP3A) expression by activating PXR. Benzophenone-2 is promising for research of UV filters[1][2].

• Product Name Alternative:

  2,2′,4,4′-Tetrahydroxybenzophenone

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H317, H319

• Target:

  Estrogen Receptor/ERR; Pregnane X Receptor (PXR)

• Related Pathways:

  Vitamin D Related/Nuclear Receptor

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Others

• Purity:

  99.68

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(C1=CC=C(O)C=C1O)C2=CC=C(O)C=C2O

• Molecular Formula:

  C13H10O5

• Molecular Weight:

  246.22

• Precautions:

  H302, H317, H319

• References & Citations:

  [1]Hu X, et al. Evaluation of polyhydroxybenzophenones as α-glucosidase inhibitors. Arch Pharm (Weinheim) . 2011 Feb;344 (2) :71-7.|[2]Casiano-Muñiz IM, et al. UV filter benzophenone-2: Effects on zebrafish (Danio rerio) cytochrome P450. Aquat Toxicol. 2024 Aug;273:106973.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  RT, stored under nitrogen

• Scientific Category:

  Reference compound2

• Clinical Information:

  No Development Reported

• CAS Number:

  [131-55-5]