Benzophenone-2

• Description :

  Benzophenone-2 (2,2',4,4'-Tetrahydroxybenzophenone) is an endocrine disruptor targeting pregnane X receptor (PXR) and estrogen receptor α (ERα) . Benzophenone-2 regulates cytochrome P450 3A (CYP3A) expression by activating PXR. Benzophenone-2 is promising for research of UV filters[1][2].

• Product Name Alternative :

  2,2′,4,4′-Tetrahydroxybenzophenone

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H317, H319

• Target :

  Estrogen Receptor/ERR; Pregnane X Receptor (PXR)

• Related Pathways :

  Vitamin D Related/Nuclear Receptor

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Others

• Purity :

  99.68

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(C1=CC=C(O)C=C1O)C2=CC=C(O)C=C2O

• Molecular Formula :

  C13H10O5

• Molecular Weight :

  246.22

• Precautions :

  H302, H317, H319

• References & Citations :

  [1]Hu X, et al. Evaluation of polyhydroxybenzophenones as α-glucosidase inhibitors. Arch Pharm (Weinheim) . 2011 Feb;344 (2) :71-7.|[2]Casiano-Muñiz IM, et al. UV filter benzophenone-2: Effects on zebrafish (Danio rerio) cytochrome P450. Aquat Toxicol. 2024 Aug;273:106973.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  RT, stored under nitrogen

• Scientific Category :

  Reference compound2

• Clinical Information :

  No Development Reported

• CAS Number :

  [131-55-5]