Fluorene-d8

CAT: 0804-HY-W026772S1-01Size: 100 mgDry Ice: NoHazardous: No
CAT#:0804-HY-W026772S1-01Size:100 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Fluorene-d8 is the deuterium labeled Fluorene (HY-W026772) . Fluorene is an orally active polycyclic aromatic hydrocarbon (PAH) and a precursor to other fluorene-based compounds. Fluorene and its derivatives serve as dye precursors for fluorene synthesis. In A549 cells, Fluorene induces oxidative stress and inflammatory responses by increasing ROS and SOD generation, exacerbating lipid peroxidation, modulating antioxidant enzyme activity, and upregulating the expression of pro-inflammatory factors TNF-α and IL-6. In vivo, Fluorene exhibits anxiolytic activity. Fluorene holds potential for research in inflammation and neurological disorders[1][2][3].
CAS Number
[35782-21-9]
UNSPSC
12352005
Target
Fluorescent Dye; Interleukin Related; Isotope-Labeled Compounds; Reactive Oxygen Species (ROS) ; SOD; TNF Receptor
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
[2H]C1=C2C3=C([2H])C([2H])=C([2H])C([2H])=C3CC2=C([2H])C([2H])=C1[2H]
Molecular Formula
C13H2D8
Molecular Weight
174.27
References & Citations
[1]Paul Olusegun Bankole, et al. Biodegradation of fluorene by the newly isolated marine-derived fungus, Mucor irregularis strain bpo1 using response surface methodology. Ecotoxicol Environ Saf. 2021 Jan 15;208:111619. |[2]Guo H, et al. Oxidative stress and inflammatory effects in human lung epithelial A549 cells induced by phenanthrene, fluorene, and their binary mixture. Environ Toxicol. 2021 Jan;36 (1) :95-104. |[3]Peiffer J, et al. Behavioral toxicity and physiological changes from repeated exposure to fluorene administered orally or intraperitoneally to adult male Wistar rats: A dose–response study[J]. Neurotoxicology, 2016, 53: 321-333.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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