Fludioxonil-13C3

CAT: 0804-HY-W021040SSize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-W021040SSize:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Fludioxonil-13C3 (CGA-173506-13C3) is 13C labeled Fludioxonil. Fludioxonil (CGA-173506) is a phenylpyrrole-type fungicide with oral activity that can inhibit the growth of S. sclerotiorum. Fludioxonil promotes tumor growth and metastasis, and induces cardiac toxicity. Fludioxonil causes cytoskeletal disruption, DNA damage, and apoptosis in mouse glioma cells[1][2][3][4].
CAS Number
[1185003-07-9]
Product Name Alternative
CGA-173506-13C3
UNSPSC
12352005
Target
Apoptosis; Fungal; Isotope-Labeled Compounds
Related Pathways
Anti-infection; Apoptosis; Others
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Smiles
FC1(OC2=C([13C]3=CNC=[13C]3[13C]#N)C=CC=C2O1)F
Molecular Formula
C9 13C3H6F2N2O2
Molecular Weight
251.16
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Yabing Duan, et al. effect of phenylpyrrole fungicide fludioxonil on morphological and physiological characteristics of Sclerotinia sclerotiorum. Pesticide Biochemistry and Physiology Volume 106, Issues 1-2, May-June 2013, Pages 61-67.|[3]Ryeo-Eun Go, et al. Fludioxonil induced the cancer growth and metastasis via altering epithelial-mesenchymal transition via an estrogen receptor-dependent pathway in cellular and xenografted breast cancer models. Environ Toxicol. 2017 Apr;32 (4) :1439-1454. |[4]Imen Graiet, et al. Fludioxonil, a phenylpyrrol pesticide, induces Cytoskeleton disruption, DNA damage and apoptosis via oxidative stress on rat glioma cells. Food Chem Toxicol. 2022 Dec:170:113464.|[5]Su-Min Seong, et al. Fludioxonil induces cardiotoxicity via mitochondrial dysfunction and oxidative stress in two cardiomyocyte models. Environ Toxicol. 2024 May;39 (5) :2993-3002.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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