Fludioxonil

• Description :

  Fludioxonil (CGA-173506) is a phenylpyrrole-type fungicide with oral activity that can inhibit the growth of S. sclerotiorum. Fludioxonil promotes tumor growth and metastasis, and induces cardiac toxicity. Fludioxonil causes cytoskeletal disruption, DNA damage, and apoptosis in mouse glioma cells[1][2][3][4].

• Product Name Alternative :

  CGA-173506

• UNSPSC :

  12352200

• Hazard Statement :

  H410

• Target :

  Apoptosis; Fungal

• Type :

  Biochemical Assay Reagents

• Related Pathways :

  Anti-infection; Apoptosis

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Infection

• Assay Protocol :

  https://www.medchemexpress.com/fludioxonil.html

• Purity :

  99.97

• Solubility :

  DMSO : 200 mg/mL (ultrasonic)

• Smiles :

  N#CC1=CNC=C1C2=C3OC(F)(F)OC3=CC=C2

• Molecular Formula :

  C12H6F2N2O2

• Molecular Weight :

  248.19

• Precautions :

  H410

• References & Citations :

  [1]Yabing Duan, et al. effect of phenylpyrrole fungicide fludioxonil on morphological and physiological characteristics of Sclerotinia sclerotiorum. Pesticide Biochemistry and Physiology Volume 106, Issues 1-2, May-June 2013, Pages 61-67.|[2]Ryeo-Eun Go, et al. Fludioxonil induced the cancer growth and metastasis via altering epithelial-mesenchymal transition via an estrogen receptor-dependent pathway in cellular and xenografted breast cancer models. Environ Toxicol. 2017 Apr;32 (4) :1439-1454. |[3]Imen Graiet, et al. Fludioxonil, a phenylpyrrol pesticide, induces Cytoskeleton disruption, DNA damage and apoptosis via oxidative stress on rat glioma cells. Food Chem Toxicol. 2022 Dec:170:113464.|[4]Su-Min Seong, et al. Fludioxonil induces cardiotoxicity via mitochondrial dysfunction and oxidative stress in two cardiomyocyte models. Environ Toxicol. 2024 May;39 (5) :2993-3002.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Biochemical Assay Reagents

• Clinical Information :

  No Development Reported

• CAS Number :

  [131341-86-1]