Products for Research Use Only
RegisterLogin

TBPH

CAT: 0804-HY-W018587Size: 1 gDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-W018587Size:1 g
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
TBPH is a brominated flame retardant. TBPH enhances hepatic steatosis, inflammation, and fibrosis in mice with nonalcoholic steatohepatitis (NASH) . TBPH induces dysregulation of phospholipid metabolism, reducing cardiolipin (CL) and phosphatidylserine (PS) levels. TBPH leads to impaired endoplasmic reticulum-mitochondria (ER-Mito) contacts, subsequently causing mitochondrial dysfunction. TBPH induces lung injury through an inflammatory response mediated by mitochondria-derived ds-DNA. TBPH can be used to study the role of MFN2-mediated ER-mitochondria contacts in lipid metabolism homeostasis[1][2].
CAS Number
26040-51-7
UNSPSC
12352005
Hazard Statement
H227, H315, H319, H335
Target
ClpP; Cytochrome P450; Eukaryotic Initiation Factor (eIF) ; HSP; Interleukin Related; LDLR; Mitochondrial Metabolism; TNF Receptor
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology
Purity
95.26
Solubility
DMSO : ≥ 175 mg/mL
Smiles
O=C(OCC(CC)CCCC)C1=C(Br)C(Br)=C(Br)C(Br)=C1C(OCC(CC)CCCC)=O
Molecular Formula
C24H34Br4O4
Molecular Weight
706.14
Precautions
H227, H315, H319, H335
References & Citations
[1]Zhou Y, Li B, Zhao J, Ren X, Guo Y, Yang L, Han J, Wu L, Zhou B. Bis (2-Ethylhexyl) -2,3,4,5-Tetrabromophthalate Promotes NASH Progression through Disrupting Endoplasmic Reticulum-Mitochondria Contacts. Environ Sci Technol. 2025 Jul 22;59 (28) :14302-14313. |[2]Xing B, et al. TBPH-induced lung injury is induced by mitochondrial-derived ds-DNA-mediated inflammatory response. Ecotoxicol Environ Saf. 2024 Nov 1;286:117200.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Scientific Category
Reference compound2
Clinical Information
No Development Reported

Related Products

CatalogName
HY-14562-01TBPB
HY-115575-01TBPC
HY-172940TBP-134
HY-P87218Tbp7 Antibody (YA6906, Rabbit)
HY-RS14266TBP Human Pre-designed siRNA Set A
HY-RS18225Tbp Mouse Pre-designed siRNA Set A
HY-RS24702Tbp Rat Pre-designed siRNA Set A
HY-P83600-01TBP Like 1 Antibody (YA3345, Rabbit)

Alternative Products

CatalogName
GTR19264059-01TBPH
GTR19273519-01TBPH-1
DZ33965Anti-Fruit fly TBPH Antibody
GTR18087771Fruit fly TBPH Rabbit Polyclonal Antibody
DZ33965-APCAnti-Fruit fly TBPH Antibody, APC Conjugate
GTR18737022Fruit fly TBPH Rabbit Polyclonal Antibody (Fluoro550)
GTR18737020Fruit fly TBPH Rabbit Polyclonal Antibody (Fluoro647)
GTR18525181Fruit fly TBPH Rabbit Polyclonal Antibody (FITC)
DZ33965-Dylight488Anti-Fruit fly TBPH Antibody (Dylight488 Conjugate)
DZ33965-Dylight550Anti-Fruit fly TBPH Antibody, Dylight550 Conjugate

Popular Products