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TBPH

CAT: 0013-GTR19264059-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19264059-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TBPH exacerbates liver steatosis, inflammation, and fibrosis in non-alcoholic steatohepatitis (NASH) mouse models. It induces phospholipid metabolism disorders, reducing cardiolipin (CL) and phosphatidylserine (PS) levels. TBPH impairs endoplasmic reticulum-mitochondria (ER-Mito) contact, leading to mitochondrial dysfunction. Additionally, TBPH causes lung injury through mitochondrial-derived ds-DNA-mediated inflammatory responses. TBPH is utilized to study the role of MFN2-mediated ER-Mito contact in lipid metabolism homeostasis.
Field of Research
Cell Biology, Immunology & Inflammation, Metabolism Research, Protein Biochemistry, Signal Transduction
Storage Conditions
-20°C
Notes
For research use only.

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